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Gene Symbol ATF7IP
Synonyms AM | ATF-IP | MCAF | MCAF1 | p621
Gene Description ATF7IP, activating transcription factor 7 interacting protein, is an epigenetic regulator and transcriptional cofactor that can act as an activator or repressor (PMID: 19106100), and functions in the regulation of SETDB1 activity (PMID: 31576654), formation of H3K9me3, and Th17 differentiation (PMID: 31217192). An ATF7IP-JAK2 fusion has been observed in acute lymphoblastic leukemia (PMID: 25207766) and an ATF7IP-PDGFRB fusion has been observed in acute lymphoblastic leukemia (PMID: 29133777).


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