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Gene Symbol AXL
Synonyms ARK | JTK11 | Tyro7 | UFO
Gene Description AXL, AXL receptor tyrosine kinase, is a receptor tyrosine kinase, which promotes growth, migration, and survival of tumor cells through activation of Mapk signaling (PMID: 28072762). Activation and overexpression of AXL has been associated with resistance to chemotherapeutic agents and targeted therapies (PMID: 28251492), in both solid and hematological tumors (PMID: 32148495).

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
A273V missense unknown AXL A273V lies within fibronectin type-III domain 1 of the Axl protein (UniProt.org). A273V has been associated with resistance to EGFR inhibitors (Cancer Res 2018;78(13 Suppl): nr 4903), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Jun 2022). Y
A674V missense unknown AXL A674V lies within the protein kinase domain of the Axl protein (UniProt.org). A674V has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
A857V missense no effect - predicted AXL A857V does not lie within any known functional domains of the Axl protein (UniProt.org). A857V has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Axl (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
act mut unknown gain of function AXL act mut indicates that this variant results in a gain of function in the Axl protein. However, the specific amino acid change has not been identified.
amp none no effect AXL amp indicates an increased number of copies of the AXL gene. However, the mechanism causing the increase is unspecified.
AXL - MBIP fusion gain of function - predicted AXL-MBIP results from fusion of AXL and MBIP, and is predicted to result in a gain of protein function as indicated by transforming ability in culture and in animal models (Cancer Res 2017;77(13 Suppl):Abstract nr 4191). AXL-MBIP has been identified in lung adenocarcinoma (PMID: 22975805).
C117R missense unknown AXL C117R lies within Ig-like C2-type domain 1 of the Axl protein (UniProt.org). C117R has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
C311F missense unknown AXL C311F lies within fibronectin type-III domain 1 of the Axl protein (UniProt.org). C311F induces similar cell proliferation and cell viability as wild-type Axl in one of two cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
D382G missense unknown AXL D382G lies within fibronectin type-III domain 2 of the Axl protein (UniProt.org). D382G has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
E388D missense unknown AXL E388D lies within fibronectin type-III domain 2 of the Axl protein (UniProt.org). E388D has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
E524K missense unknown AXL E524K lies within the cytoplasmic domain of the Axl protein (UniProt.org). E524K has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
E818K missense unknown AXL E818K lies within the cytoplasmic domain of the Axl protein (UniProt.org). E818K has been identified in the scientific literature (PMID: 25452114), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
F631S missense unknown AXL F631S lies within the protein kinase domain of the Axl protein (UniProt.org). F631S has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
F652L missense unknown AXL F652L lies within the protein kinase domain of the Axl protein (UniProt.org). F652L has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G331A missense unknown AXL G331A lies within fibronectin type-III domain 1 of the Axl protein (UniProt.org). G331A has been identified in sequencing studies (PMID: 24121792), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G335fs frameshift loss of function - predicted AXL G335fs results in a change in the amino acid sequence of the Axl protein beginning at aa 335 of 894, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), G335fs is predicted to lead to a loss of Axl protein function.
G413V missense loss of function - predicted AXL G413V lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). G413V has not been biochemically characterized, but results in decreased cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to result in a loss of Axl protein function.
G413W missense unknown AXL G413W lies within fibronectin type-III domain 2 of the Axl protein (UniProt.org). G413W has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G415A missense unknown AXL G415A lies within fibronectin type-III domain 2 of the Axl protein (UniProt.org). G415A has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G46V missense unknown AXL G46V lies within Ig-like C2-type domain 1 of the Axl protein (UniProt.org). G46V has been identified in sequencing studies (PMID: 22895193), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G517S missense unknown AXL G517S lies within the cytoplasmic domain of the Axl protein (UniProt.org). G517S has been identified in sequencing studies (PMID: 18056464, PMID: 29681454), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G692R missense unknown AXL G692R lies within the protein kinase domain of the Axl protein (UniProt.org). G692R has been identified in sequencing studies (PMID: 24265153), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G736R missense unknown AXL G736R lies within the protein kinase domain of the Axl protein (UniProt.org). G736R has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G736W missense loss of function - predicted AXL G736W lies within the protein kinase domain of the Axl protein (UniProt.org). G736W has not been biochemically characterized, but results in decreased cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to result in a loss of Axl protein function.
G73V missense unknown AXL G73V lies within Ig-like C2-type domain 1 of the Axl protein (UniProt.org). G73V has been identified in sequencing studies (PMID: 26168399), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
G89D missense unknown AXL G89D lies within Ig-like C2-type domain 1 of the Axl protein (UniProt.org). G89D has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
H670Q missense unknown AXL H670Q lies within the protein kinase domain of the Axl protein (UniProt.org). H670Q has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
I466L missense unknown AXL I466L lies within the transmembrane domain of the Axl protein (UniProt.org). I466L has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Aug 2022).
I619V missense unknown AXL I619V lies within the protein kinase domain of the Axl protein (UniProt.org). I619V has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
I656N missense unknown AXL I656N lies within the protein kinase domain of the Axl protein (UniProt.org). I656N has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
I758M missense unknown AXL I758M lies within the protein kinase domain of the Axl protein (UniProt.org). I758M has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
inact mut unknown loss of function AXL inact mut indicates that this variant results in a loss of function of the Axl protein. However, the specific amino acid change has not been identified.
K476T missense unknown AXL K476T lies within the cytoplasmic domain of the Axl protein (UniProt.org). K476T has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
K567M missense loss of function - predicted AXL K567M lies within the protein kinase domain of the Axl protein (UniProt.org). K567M results in a loss of the ATP-binding site, and impaired binding to Plc gamma, P85, Grb2, C-src and Lck in an in vitro assay (PMID: 9178760), and therefore, is predicted to result in a loss of Axl protein function.
K567R missense loss of function - predicted AXL K567R lies within the ATP-binding site and protein kinase domain of the Axl protein (UniProt.org). K567R results in a loss of ubiquitination leading to increased Axl accumulation at the cell surface in culture (PMID: 31171001), and therefore, is predicted to lead to a loss of Axl protein function.
L423Q missense loss of function - predicted AXL L423Q lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). L423Q has not been biochemically characterized, but results in decreased cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to result in a loss of Axl protein function.
L455I missense unknown AXL L455I lies within the transmembrane domain of the Axl protein (UniProt.org). L455I has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
L54F missense unknown AXL L54F lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). L54F has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
L54I missense unknown AXL L54I lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). L54I has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
L693P missense unknown AXL L693P lies within the protein kinase domain of the Axl protein (UniProt.org). L693P has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
L721P missense unknown AXL L721P lies within the protein kinase domain of the Axl protein (UniProt.org). L721P has not been characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
M569I missense unknown AXL M569I lies within the protein kinase domain of the Axl protein (UniProt.org). M569I has been identified in sequencing studies (PMID: 18056464), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
M589K missense unknown AXL M589K lies within the protein kinase domain of the Axl protein (UniProt.org). M589K has been identified in sequencing studies (PMID: 27573823), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
mutant unknown unknown AXL mutant indicates an unspecified mutation in the AXL gene.
N266D missense unknown AXL N266D lies within fibronectin type-III domain 1 of the Axl protein (UniProt.org). N266D has been identified in sequencing studies (PMID: 25528188), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Apr 2022).
N43T missense unknown AXL N43T lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). N43T has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
N677I missense unknown AXL N677I lies within the protein kinase domain of the Axl protein (UniProt.org). N677I has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
negative unknown loss of function AXL negative indicates a lack of expression of the AXL mRNA and/or protein.
over exp none no effect AXL over exp indicates an over expression of the Axl protein. However, the mechanism causing the over expression is unspecified.
P168S missense unknown AXL P168S lies within the Ig-like C2-type domain 2 of the Axl protein (UniProt.org). P168S has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
P337Lfs*29 frameshift loss of function - predicted AXL P337Lfs*29 indicates a shift in the reading frame starting at amino acid 337 and terminating 29 residues downstream causing a premature truncation of the 894 amino acid Axl protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), P337Lfs*29 is predicted to lead to a loss of Axl protein function.
P444S missense no effect - predicted AXL P444S does not lie within any known functional domains of the Axl protein (UniProt.org). P444S has not been biochemically characterized, but results in similar cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
P595S missense unknown AXL P595S lies within the protein kinase domain of the Axl protein (UniProt.org). P595S has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
P645H missense unknown AXL P645H lies within the protein kinase domain of the Axl protein (UniProt.org). P654H has been identified in sequencing studies (PMID: 21097718), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Jun 2022).
P64S missense unknown AXL P64S lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). P64S has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
P811S missense unknown AXL P811S lies within the cytoplasmic domain of the Axl protein (UniProt.org). P811S has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
positive unknown unknown AXL positive indicates the presence of the AXL gene, mRNA, and/or protein.
Q59H missense unknown AXL Q59H lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). Q59H has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
Q764R missense unknown AXL Q764R lies within the protein kinase domain of the Axl protein (UniProt.org). Q764R has been identified in the scientific literature (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
Q83R missense unknown AXL Q83R lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). Q83R induces similar cell proliferation and cell viability as wild-type Axl in one of two cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R217H missense unknown AXL R217H lies within the Ig-like C2-type domain 2 of the Axl protein (UniProt.org). R217H has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R229C missense unknown AXL R229C lies within fibronectin type-III domain 1 of the Axl protein (UniProt.org). R229C has not been characterized and therefore, its effect on Axl protein function is unknown (PubMed, Jun 2022).
R295W missense unknown AXL R295W lies within the fibronectin type-III domain 1 of the Axl protein (UniProt.org). R295W has been identified in sequencing studies (PMID: 27592799, PMID: 16140923), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R308C missense unknown AXL R308C lies within the fibronectin type-III domain 1 of the Axl protein (UniProt.org). R308C has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R357W missense unknown AXL R357W lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). R357W has been identified in sequencing studies (PMID: 27507618), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R368Q missense unknown AXL R368Q lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). R368Q has been identified in sequencing studies (PMID: 22722839, PMID: 34465320), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R368W missense unknown AXL R368W lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). R368W has been identified in sequencing studies (PMID: 25922291), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R427C missense unknown AXL R427C lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). R427C has been identified in sequencing studies (PMID: 26000489), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R475Q missense unknown AXL R475Q lies within the cytoplasmic domain of the Axl protein (UniProt.org). R475Q has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R48W missense unknown AXL R48W lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). R48W has been identified in sequencing studies (PMID: 24755471), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R506C missense no effect - predicted AXL R506C does not lie within any known functional domains of the Axl protein (UniProt.org). R506C has not been biochemically characterized, but results in similar cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
R506H missense no effect - predicted AXL R506H lies within the cytoplasmic domain of the Axl protein (UniProt.org). R506H has not been biochemically characterized, but results in similar cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
R507W missense unknown AXL R507W lies within the cytoplasmic domain of the Axl protein (UniProt.org). R507W has been identified in sequencing studies (PMID: 27149842), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R527L missense no effect - predicted AXL R527L lies within the cytoplasmic domain of the Axl protein (UniProt.org). R527L has not been biochemically characterized, but results in similar cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
R527W missense unknown AXL R527W lies within the cytoplasmic domain of the Axl protein (UniProt.org). R527W has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R55Q missense unknown AXL R55Q lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). R55Q has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R610Q missense unknown AXL R610Q lies within the protein kinase domain of the Axl protein (UniProt.org). R610Q has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R671Q missense unknown AXL R671Q lies within the protein kinase domain of the Axl protein (UniProt.org). R671Q has been identified in sequencing studies (PMID: 25855536), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Mar 2022).
R71W missense unknown AXL R71W lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). R71W has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
R800L missense no effect - predicted AXL R800L lies within the cytoplasmic domain of the Axl protein (UniProt.org). R800L has not been biochemically characterized, but results in similar cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
rearrange unknown unknown AXL rearrange indicates an unspecified rearrangement of the AXL gene.
S128F missense unknown AXL S128F lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). S128F has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
S265A missense unknown AXL S265A lies within fibronectin type-III domain 1 of the Axl protein (UniProt.org). S265A has been identified in sequencing studies (PMID: 31328403), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Jun 2022).
S285L missense unknown AXL S285L lies within the fibronectin type-III domain 1 of the Axl protein (UniProt.org). S285L has been identified in sequencing studies (PMID: 24265153), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
S341G missense unknown AXL S341G lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). S341G has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
S685F missense unknown AXL S685F lies within the protein kinase domain of the Axl protein (UniProt.org). S685F has been identified in the scientific literature (PMID: 25568918), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
S694F missense unknown AXL S694F lies within the protein kinase domain of the Axl protein (UniProt.org). S694F has not been characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
T343M missense unknown AXL T343M lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). T343M has been identified in the scientific literature (PMID: 33570712), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
T568M missense no effect - predicted AXL T568M lies within the cytoplasmic domain of the Axl protein (UniProt.org). T568M has not been biochemically characterized, but results in similar cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
V289M missense unknown AXL V289M lies within the fibronectin type-III domain 1 of the Axl protein (UniProt.org). V289M has been identified in sequencing studies (PMID: 22610119), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
V421L missense unknown AXL V421L lies within fibronectin type-III domain 2 of the Axl protein (UniProt.org). V421L has been identified in sequencing studies (PMID: 32321774), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Jun 2022).
V459M missense unknown AXL V459M lies within the transmembrane domain of the Axl protein (UniProt.org). V459M has been identified in sequencing studies (PMID: 26675719), but has not been biochemically characterized and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
V60F missense unknown AXL V60F lies within the Ig-like C2-type domain 1 of the Axl protein (UniProt.org). V60F has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Mar 2022).
V618I missense unknown AXL V618I lies within the protein kinase domain of the Axl protein (UniProt.org). V618I has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
W426R missense no effect - predicted AXL W426R does not lie within any known functional domains of the Axl protein (UniProt.org). W426R has not been biochemically characterized, but results in similar cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to have no effect on Axl protein function.
W69* nonsense loss of function - predicted AXL W69* results in a premature truncation of the Axl protein at amino acid 69 of 894 (UniProt.org). W69* has not been biochemically characterized, but results in decreased cell proliferation and viability compared to wild-type Axl in culture (PMID: 29533785), and therefore, is predicted to result in a loss of Axl protein function.
wild-type none no effect Wild-type AXL indicates that no mutation has been detected within the AXL gene.
Y367C missense unknown AXL Y367C lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). Y367C has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
Y371C missense unknown AXL Y371C lies within the fibronectin type-III domain 2 of the Axl protein (UniProt.org). Y371C has not been characterized in the scientific literature and therefore, its effect on Axl protein function is unknown (PubMed, Feb 2022).
Y779F missense unknown AXL Y779F lies within the protein kinase domain of the Axl protein (UniProt.org). Y779F demonstrates similar binding to Abl2 in the presence of ligand in cell culture (PMID: 31825826) and confers resistance Erbitux (cetuximab) in cell culture (PMID: 32439698), but has not been fully biochemically characterized and therefore, its effect on Axl protein function is unknown. Y
Y821F missense loss of function - predicted AXL Y821F lies within the protein kinase domain of the Axl protein (PMID: 31825826). Y821F demonstrates reduced binding to Abl2 in the presence of ligand in cell culture (PMID: 31825826), and therefore, is predicted to result in a loss of Axl protein function.
Y866F missense no effect - predicted AXL Y866F lies within the protein kinase domain of the Axl protein (PMID: 31825826). Y866F has been demonstrated to confer resistance to Egfr inhibitors in culture (PMID: 32439698), but demonstrates similar binding to Abl2 in the presence of ligand (PMID: 31825826), and does not induce cellular transformation in culture (PMID: 9671397), and therefore, is predicted to have no effect on Axl protein function. Y