Gene Detail

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Gene Symbol AXL
Synonyms ARK | JTK11 | Tyro7 | UFO
Gene Description AXL, AXL receptor tyrosine kinase, is a receptor tyrosine kinase, which promotes growth, migration, and survival of tumor cells through activation of Mapk signaling (PMID: 28072762). Activation and overexpression of AXL has been associated with resistance to chemotherapeutic agents and targeted therapies (PMID: 28251492), in both solid and hematological tumors (PMID: 32148495).

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
act mut unknown gain of function AXL act mut indicates that this variant results in a gain of function in the Axl protein. However, the specific amino acid change has not been identified.
inact mut unknown loss of function AXL inact mut indicates that this variant results in a loss of function of the Axl protein. However, the specific amino acid change has not been identified.
mutant unknown unknown AXL mutant indicates an unspecified mutation in the AXL gene.
rearrange unknown unknown AXL rearrange indicates an unspecified rearrangement of the AXL gene.
G335fs frameshift loss of function - predicted AXL G335fs results in a change in the amino acid sequence of the Axl protein beginning at aa 335 of 894, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), G335fs is predicted to lead to a loss of Axl protein function.