Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||DBK | PAK-1 | PAK1 | PKN | PKN-ALPHA | PRK1 | PRKCL1|
|Gene Description||PKN1, protein kinase N1, is a member of the protein kinase C superfamily that mediates Rho-dependent signaling pathways, thus regulates cell migration, invasion, and gene expression (PMID: 25504435, PMID: 28222172). Increased Pkn1 expression has been identified in glioma, kidney, ovarian, and prostate cancer, and pancreatic ductal adenocarcinoma (PMID: 30206226) and a fusion with HTT has been observed in pigmented epithelioid melanocytoma (PMID: 31972666).|