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|Synonyms||DNA-PKC | DNA-PKcs | DNAPK | DNAPKc | DNPK1 | HYRC | HYRC1 | IMD26 | p350 | XRCC7|
|Gene Description||PRKDC, protein kinase, DNA-activated, catalytic subunit, is the catalytic component of the DNA-PK complex, which functions in DNA repair by non-homologous end-joining (PMID: 14726021, PMID: 24680878). PRKDC overexpression has been demonstrated in colorectal cancer (PMID: 26992638), prostate cancer (PMID: 27856181), and gastric cancer (PMID: 31255330), and PRKDC mutations may be predictive of response to immunotherapy in lung cancer, melanoma, and renal cell carcinoma (PMID: 32238472).|