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Gene Symbol MAP2K2
Synonyms CFC4 | MAPKK2 | MEK2 | MKK2 | PRKMK2
Gene Description MAP2K2 (MEK2), mitogen-activated protein kinase kinase 2, is a serine-threonine kinase, which activates that RAS-RAF-MEK-ERK pathway to regulate, the cell cycle, cell proliferation, and cell differentiation (PMID: 22753777, PMID: 29706623). MAP2K2 (MEK2) missense mutations are commonly associated with acquired resistance to RAF and MEK inhibitors (PMID: 24265153, PMID: 28263969, PMID: 28655712).


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