Gene Detail


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Gene Symbol HTRA1
Synonyms ARMD7 | CADASIL2 | CARASIL | HtrA | L56 | ORF480 | PRSS11
Gene Description HTRA1, HtrA serine peptidase 1, is a serine protease and member of the high temperature requirement family, and plays a role in protein degradation, homeostasis (PMID: 29863874) ,and cell signaling, specifically through the TGF-B pathway (PMID: 24040176). Reduced expression of HTRA1 has been observed in a variety of tumor types including urothelial bladder, esophageal, liver, and endometrial cancer (PMID: 26035313, PMID: 29409460).
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