Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | B2M | ||||||||||
| Synonyms | IMD43 | ||||||||||
| Gene Description | B2M, beta-2-microglobulin, forms the light chain of the class I major histocompatibility complex (MHC) (PMID: 3312414) and is required for antigen presentation during the immune response (PMID: 27433843). B2M loss of function mutations have been associated with mismatch repair (MMR) deficiency in colon cancer (PMID: 28616688) and with acquired resistance to immune checkpoint inhibitors in melanoma (PMID: 27433843, PMID: 30466478). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
