Gene Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
| Gene Symbol | PTK2 | ||||||||||
| Synonyms | FADK | FADK 1 | FAK | FAK1 | FRNK | p125FAK | pp125FAK | PPP1R71 | ||||||||||
| Gene Description | PTK2, protein tyrosine kinase 2, encodes for a focal adhesion, non-receptor protein tyrosine kinase (PMID: 31791326), which once activated via integrins, signals various molecules involved in the regulation of cell proliferation, apoptosis, survival, and migration (PMID: 12371144). Increased activation of Ptk2 has been observed in ovarian cancer, which has been linked to PTK2 amplification (PMID: 24755674), and overexpression in breast, ovarian, colorectal, and lung cancers has been associates with decreased survival (PMID: 31791326), and a circRNA of PTK2 has been implicated in tumor growth and metastasis in colorectal cancer (PMID: 31973707). | ||||||||||
|
|||||||||||
Additional content available in 
CKB BOOST
CKB BOOST
