Gene Detail

Gene Symbol PTK2
Synonyms FADK | FAK | FAK1 | FRNK | p125FAK | pp125FAK | PPP1R71
Gene Description PTK2, protein tyrosine kinase 2, encodes for a focal adhesion tyrosine kinase, which once activated via integrins, signals various molecules involved in the regulation of cell proliferation, apoptosis, survival, and migration (PMID: 12371144). Increased activation of Ptk2 has been observed in ovarian cancer, which has been linked to PTK2 amplification (PMID: 24755674).
Entrez Id 5747
Chromosome 8
Map Location 8q24.3
Canonical Transcript NM_153831

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