Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol PTPN11
Synonyms BPTP3 | CFC | JMML | METCDS | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2
Gene Description PTPN11, protein tyrosine phosphatase non-receptor type 11, is a member of the PTP Src homology-2 (SH2) domain-containing phosphatases that induces the MAPK signal transduction pathway to regulate growth factor signaling and has been characterized as both an oncogene and tumor suppressor (PMID: 20337577, PMID: 28074573). PTPN11 activating mutations have been identified in a variety of tumors including, lung, colon, brain, thyroid, skin and heme (PMID: 18286234, PMID: 21407260), PTPN11 hypomethylation has been observed in gastric cancer (PMID: 32194661), and germline mutations are implicated in Noonan syndrome (PMID: 28328117, PMID: 32233106).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PTPN11 A461G unknown
PTPN11 A461T loss of function
PTPN11 A72D gain of function - predicted SHP2 Inhibitor
FLT3 D835Y PTPN11 A72D
PTPN11 A72G unknown
PTPN11 A72S gain of function - predicted SHP2 Inhibitor
PTPN11 A72T unknown
PTPN11 A72V gain of function SHP2 Inhibitor
PTPN11 act mut gain of function SHP2 Inhibitor
PTPN11 D106A gain of function - predicted SHP2 Inhibitor
PTPN11 D106Y unknown
PTPN11 D146Y unknown
PTPN11 D155Y unknown
PTPN11 D473N unknown
PTPN11 D61G gain of function
PTPN11 D61H unknown
PTPN11 D61N unknown SHP2 Inhibitor
PTPN11 D61Y gain of function SHP2 Inhibitor
PTPN11 dec exp no effect
BRAF mut PTPN11 dec exp
PTPN11 E123D unknown
PTPN11 E139D no effect - predicted
PTPN11 E139K unknown
PTPN11 E225D unknown
PTPN11 E69D unknown
PTPN11 E69K unknown
PTPN11 E76A gain of function - predicted SHP2 Inhibitor
PTPN11 E76G gain of function SHP2 Inhibitor
PTPN11 E76K gain of function SHP2 Inhibitor
BRAF G596R PTPN11 E76K
PTPN11 E76Q no effect - predicted
PTPN11 E76V gain of function - predicted
PTPN11 F285L unknown
PTPN11 F285S gain of function
PTPN11 F341Y unknown
PTPN11 F71I gain of function - predicted SHP2 Inhibitor
PTPN11 F71L unknown
PTPN11 G13D unknown
PTPN11 G464D unknown
PTPN11 G503E unknown
PTPN11 G503L unknown
PTPN11 G503R unknown
PTPN11 G503V gain of function - predicted SHP2 Inhibitor
PTPN11 G60R no effect - predicted
PTPN11 G60V unknown
PTPN11 H114Y unknown
PTPN11 I172T unknown
PTPN11 I282M unknown
PTPN11 I282V gain of function - predicted SHP2 Inhibitor
PTPN11 I54T unknown
PTPN11 inact mut loss of function
PTPN11 K325T unknown
PTPN11 K55N unknown
PTPN11 L117F unknown
PTPN11 L136H unknown
PTPN11 L262F gain of function
PTPN11 loss loss of function
PTPN11 M311V unknown
PTPN11 M504V gain of function - predicted SHP2 Inhibitor
PTPN11 M82V unknown
PTPN11 mutant unknown
IDH1 wild-type PTPN11 mut
PTPN11 N308D unknown
PTPN11 N339S unknown
PTPN11 N58K no effect - predicted
PTPN11 N58S gain of function - predicted SHP2 Inhibitor
PTPN11 N58Y unknown
PTPN11 P491L unknown
PTPN11 P491Q unknown
PTPN11 P491S gain of function - predicted
PTPN11 Q257L unknown
PTPN11 T253M PTPN11 Q257L
PTPN11 Q510E loss of function
PTPN11 Q510H unknown
PTPN11 Q510L unknown
PTPN11 Q79R unknown
PTPN11 R278K unknown
PTPN11 R384C unknown
PTPN11 R498W loss of function - predicted
PTPN11 S502A unknown
PTPN11 S502L unknown
PTPN11 S502T gain of function - predicted
PTPN11 T253M unknown
PTPN11 T337M unknown
PTPN11 T468M loss of function
PTPN11 T507K gain of function SHP2 Inhibitor
PTPN11 T52S unknown
PTPN11 T73I unknown
PTPN11 V181I unknown
PTPN11 V45L gain of function - predicted SHP2 Inhibitor
PTPN11 V51A no effect - predicted
PTPN11 wild-type no effect
PTPN11 Y279C loss of function
PTPN11 Y62C gain of function - predicted SHP2 Inhibitor
PTPN11 Y63C gain of function - predicted SHP2 Inhibitor