Gene Detail

Gene Symbol BARD1
Synonyms
Gene Description BARD1, BRCA1 associated RING domain 1, forms a heterodimer with Brca1, which functions as an E3 ubiquitin ligase and mediator of DNA repair through homology-directed repair (HDR) (PMID: 8944023, PMID: 30925164) and centrosome regulation (PMID: 29858377). Germline mutations in BARD1 are associated with increased susceptibility to breast and ovarian cancers (PMID: 21344236) and somatic mutations are highest in colon and endometrial cancers (PMID: 27283171).
Entrez Id 580
Chromosome 2
Map Location 2q35
Canonical Transcript NM_000465


Additional content available in CKB BOOST