Gene Detail


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Gene Symbol PTPRZ1
Synonyms HPTPZ | HPTPzeta | phosphacan | PTP-ZETA | PTP18 | PTPRZ | PTPZ | R-PTP-zeta-2 | RPTPB | RPTPbeta
Gene Description PTPRZ1, protein tyrosine phosphatase, receptor type Z1, encodes for a receptor that is activated by Hif2a and is involved in signal transduction and primarily expressed during central nervous system development (PMID: 20224786). PTPRZ1-MET fusions have been observed in glioma (PMID: 30343896) and overexpression of PTPRZ1 has been seen in a variety of tumors, including glioblastoma, renal carcinoma, and hepatocarcinoma (PMID: 20224786).
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