Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||AIFEC | CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | FCAS4 | IPAF|
|Gene Description||NLRC4, NLR family CARD domain containing 4, is a type of inflammasome that plays a role in the innate immune response to pathogens, which upon activation by a bacterial ligand binds and activates caspase-1, leading to pyroptosis and cell death (PMID: 32531834, PMID: 34276697). An NLRC4-ALK fusion has been identified in lung adenocarcinoma (PMID: 32212216) and increased expression of NLRC4 has been observed in glioma (PMID: 31133717).|