Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol RAD17
Synonyms CCYC | HRAD17 | R24L | RAD17SP | RAD24
Gene Description RAD17, RAD17 checkpoint clamp loader component, plays a role in DNA repair of double-strand breaks through recruitment of the MRN (MRE11-RAD50-NBS1) complex upon activation by ATM (PMID: 24619000, PMID: 24534091). Loss of Rad17 may render tumor cells sensitive to chemotherapy (PMID: 23687379, PMID: 23637229) and targeted therapies (PMID: 26513298), and overexpression has been observed in non-small cell lung cancer (PMID: 11606373).
Additional content available in CKB BOOST