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Gene Symbol RAD21
Synonyms CDLS4 | hHR21 | HR21 | HRAD21 | MCD1 | MGS | NXP1 | SCC1
Gene Description RAD21, RAD21 cohesin complex component, is a double-strand-break repair protein and member of the cohesion complex, which is responsible for maintaining sister chromatid segregation during the S-phase of the mitotic cycle (PMID: 22145905). Amplification and overexpression of Rad21 has been observed in several cancer types including breast, prostate, colorectal (PMID: 21255398, PMID: 24548858), and mutations have been identified in acute myeloid leukemia (PMID: 29288251).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD21 wild-type breast cancer not applicable N/A Preclinical Emerging In a preclinical study, siRNA inhibition of RAD21 in breast cancer cells resulted in increased sensitivity to Toposaur (etoposide) in culture, suggesting RAD21 may be a potential therapeutic target for enhanced sensitivity to chemotherapeutics (PMID: 15767545). 15767545