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Gene Symbol | RAD51D | ||||||||||
Synonyms | BROVCA4 | R51H3 | RAD51L3 | TRAD | ||||||||||
Gene Description | RAD51D, RAD51 paralog D, functions in homologous recombination in DNA repair and plays a role in telomere maintenance (PMID: 21821141, PMID: 23108668). Mutations in RAD51D are associated with increased susceptibility to ovarian cancer (PMID: 23372765, PMID: 21822267). | ||||||||||
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Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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inact mut | unknown | loss of function | RAD51D inact mut indicates that this variant results in a loss of function of the Rad51d protein. However, the specific amino acid change has not been identified. | |
K91fs | frameshift | loss of function | RAD51D K91fs results in a change in the amino acid sequence of the Rad51d protein beginning at aa 91 of 328, likely resulting in premature truncation of the functional protein (UniProt.org). K91fs results in decreased Rad51d protein stability, impaired DNA homologous recombination activity and DNA damage response, and increased sensitivity to PARP inhibitors in culture (PMID: 33151324). | |
mutant | unknown | unknown | RAD51D mutant indicates an unspecified mutation in the RAD51D gene. |