Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol RASGRF1
Synonyms CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187 | ras-GRF1
Gene Description RASGRF1, Ras protein specific guanine nucleotide releasing factor 1, is a guanine exchange factor that mediates activation of Ras and Rho family proteins by promoting GDP and GTP exchange, and plays a role in cellular proliferation, neuronal differentiation, and synaptic plasticity (PMID: 21111786). A RASGRF1 fusion with TMEM87A has been identified in non-small cell lung carcinoma (PMID: 32312893), overexpression of RASGRF1 has been identified in alveolar rhabdomyosarcoma (PMID: 22752028), and aberrant methylation of RASGRF1 has been reported in colorectal (PMID: 29530990) and gastric cancer (PMID: 22961779).


Additional content available in CKB BOOST