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|Synonyms||CDC25 | CDC25L | GNRP | GRF1 | GRF55 | H-GRF55 | PP13187 | ras-GRF1|
|Gene Description||RASGRF1, Ras protein specific guanine nucleotide releasing factor 1, is a guanine exchange factor that mediates activation of Ras and Rho family proteins by promoting GDP and GTP exchange, and plays a role in cellular proliferation, neuronal differentiation, and synaptic plasticity (PMID: 21111786). A RASGRF1 fusion with TMEM87A has been identified in non-small cell lung carcinoma (PMID: 32312893), overexpression of RASGRF1 has been identified in alveolar rhabdomyosarcoma (PMID: 22752028), and aberrant methylation of RASGRF1 has been reported in colorectal (PMID: 29530990) and gastric cancer (PMID: 22961779).|