Gene Detail

Gene Symbol RBBP8
Synonyms COM1 | CTIP | JWDS | RIM | SAE2 | SCKL2
Gene Description RBBP8, DNA endonuclease RBBP8, plays a role in transcription, DNA replication, cell-cylce transition, and DNA repair through homologous recombination repair with Brca1 (PMID: 26713604). RBBP8 expression is decreased in breast cancer and loss may be associated with sensitivity to PARP inhibitors (PMID: 26713604) and increased mutation rate in colorectal cancer (PMID: 12414815).
Entrez Id 5932
Chromosome 18
Map Location 18q11.2
Canonical Transcript NM_002894

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