Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol ACTB
Synonyms BKRNS | BNS | BRWS1 | CSMH | DDS1 | PS1TP5BP1 | THC8
Gene Description ACTB, actin beta, encodes a cytoskeletal protein that plays a role in regulating cellular pools of globular actin (PMID: 21900491), gene expression (PMID: 20053683), chromatin remodeling (PMID: 30557298, PMID: 22573825), and cell growth and migration (PMID: 21900491). Increased ACTB expression has been identified in gastric cancer (PMID: 23635433), and a fusion with FOSB has been observed in pseudomyogenic hemangioendothelioma (PMID: 30459475), and with GLI1 in pericytomas (PMID: 15111311, PMID: 15555571).
Additional content available in CKB BOOST