Gene Detail


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Gene Symbol BCL6
Synonyms BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51
Gene Description BCL6, BCL6 transcription repressor, functions as a transcriptional repressor in germinal center B cells, playing a role in B-lymphocyte development, and is critical for cell survival and proliferation (PMID: 20498019, PMID: 31788471). Increased expression of BCL6 has been associated with both solid and hematological malignancies including DLBCL, neuroblastoma, breast cancer (PMID: 24917186), and B-cell acute lymphoblastic leukemia (PMID: 31395741).
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