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Gene Symbol ROCK1
Synonyms P160ROCK | ROCK-I
Gene Description ROCK1, Rho associated coiled-coil containing protein kinase 1, is a serine/threonine kinase involved in cell contraction, motility, and survival through regulation of actomyosin dynamics (PMID: 24553779) and may play a role in tumorigenesis and metastasis (PMID: 26725045). Decreased expression of Rock1 has been reported in melanoma (PMID: 32234882), while Rock1 elevated plasma levels have been observed in pancreatic adenocarcinoma (PMID: 32104251), and overexpression has been reported in hepatocellular carcinoma (PMID: 31900116).


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