Gene Detail

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Gene Symbol

SORT1

Synonyms

Gp95 | LDLCQ6 | NT3 | NTR3

Gene Description

SORT1, sortilin 1, encodes a member of the VPS10-related sorting receptor family involved in protein trafficking (PMID: 9013611) that plays a role in cholesterol homeostasis (PMID: 20816088, PMID: 27881673) and in cell viability, proliferation, migration, and invasion (PMID: 22341525, PMID: 34162830, PMID: 35847356). Increased Sort1 expression has been observed in ovarian cancer (PMID: 25215181), hepatocellular carcinoma (PMID: 36445845) and glioblastoma (PMID: 37173980).

NCBI Gene ID	Chromosome	Map Location	Canonical Transcript	Gene Role
6272	1	1p21.3-p13.1	NM_002959	Unknown

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