Gene Detail
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| Gene Symbol | SDHC | ||||||||||
| Synonyms | CYB560 | CYBL | PGL3 | PPGL3 | QPS1 | SDH3 | ||||||||||
| Gene Description | SDHC, succinate dehydrogenase complex subunit C, is the large membrane-bound subunit of cytochrome b in mitochondrial complex II that catalyzes electron transfer from succinate to ubiquinone (PMID: 21771581). SDHC germline mutations are found paragangliomas (PMID: 19454582), pheochromocytomas (PMID: 17557926), adrenocortical carcinomas (PMID: 28819017), and somatic promoter methylation leads to decreased expression of Sdhc in parasympathetic paragangliomas (PMID: 29126304). | ||||||||||
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