Gene Detail

Gene Symbol SDHC
Synonyms CYB560 | CYBL | PGL3 | QPS1 | SDH3
Gene Description SDHC, succinate dehydrogenase cytochrome b560 subunit, mitochondrial, is the large membrane-bound subunit of cytochrome b in mitochondrial complex II that catalyzes electron transfer from succinate to ubiquinone (PMID: 21771581). SDHC germline mutations are found paragangliomas (PMID: 19454582), pheochromocytomas (PMID: 17557926), adrenocortical carcinomas (PMID: 28819017), and somatic promoter methylation leads to decreased expression of Sdhc in parasympathetic paragangliomas (PMID: 29126304).
Entrez Id 6391
Chromosome 1
Map Location 1q23.3
Canonical Transcript NM_003001

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