Gene Detail

Gene Symbol CRLF2
Synonyms CRL2 | CRLF2Y | TSLPR
Gene Description CRLF2, cytokine receptor-like factor 2 acts as a cell membrane receptor for thymic stromal lymphopoietin (TSLP), resulting in downstream activation of JAK2, STAT3 and STAT5 pathways. Mutations and rearrangements of Crlf2 are associated with acute lymphoblastic leukemeia (PMID: 22685175).
Entrez Id 64109
Chromosome X, Y
Map Location Xp22.33 and Yp11.2
Canonical Transcript NM_022148

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