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Gene Symbol CRLF2
Synonyms CRL2 | CRLF2Y | TSLPR
Gene Description CRLF2, cytokine receptor-like factor 2, acts as a cell membrane receptor for thymic stromal lymphopoietin (TSLP), resulting in downstream activation of JAK2, STAT3 and STAT5 pathways (PMID: 22685175). Mutations and rearrangements of Crlf2 are associated with acute lymphoblastic leukemeia (PMID: 22685175, PMID: 31318944, PMID: 30487598).
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