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|Synonyms||JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SAPKK-1 | SAPKK1 | SEK1 | SERK1 | SKK1|
|Gene Description||MAP2K4, mitogen-activated protein kinase kinase 4, is a member of the MAP kinase family, which activates stress-activated protein kinase/c-Jun N-terminal kinases (PMID: 10785355) and plays a role in cell proliferation, differentiation, transcriptional regulation, and development (PMID: 31761784). Overexpression of MAP2K4 has been correlated with poor survival in breast cancer (PMID: 31761784) and MAP2K4 missense mutations have been observed in breast, prostate, and colon cancers (PMID: 29795445).|