Gene Detail
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| Gene Symbol | NSD1 | ||||||||||
| Synonyms | ARA267 | KMT3B | SOTOS | SOTOS1 | STO | ||||||||||
| Gene Description | NSD1, nuclear receptor binding SET domain protein 1, is a histone methyltransferase that regulates gene expression through methylation of histone H3 lysine 36 (PMID: 21196496) and lysine 37 (H3K27me3) (PMID: 31727171) and is also a coregulator of steroid receptors (PMID: 11733144, PMID: 11509567). Overexpression of Nsd1 has been observed in metastatic pancreatic ductal adenocarcinoma (PMID: 31060750) and in hepatocellular carcinoma patients with poor prognosis (PMID: 31727171), while loss of function mutations in NSD1 may increase sensitivity to cisplatin in HPV-negative head and neck squamous cell carcinoma (PMID: 29636367). | ||||||||||
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