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|Synonyms||CFAP78 | FAP78 | RFWD2 | RNF200|
|Gene Description||COP1, constitutive photomorphogenesis protein 1, is a COP-DET-FUS family member and an ubiquitously expressed E3 ubiquitin-protein ligase that mediates substrate ubiquitinylation, and functions both as a tumor suppressor and an oncogene (PMID: 22673153, PMID: 21572435, PMID: 21403399). A fusion of COP1 with NTRK1 has been observed in large-cell neuroendocrine carcinoma (Cancer Res 2014;74(19 Suppl):Abstract nr 1531).|