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Gene Symbol SMO
Synonyms CRJS | FZD11 | Gx | PHLS | SMOH
Gene Description SMO, smoothened, frizzled class receptor, is a G-protein coupled receptor and member of the Hedgehog signaling pathway, which is involved in cell fate, proliferation, and survival (PMID: 16881963). SMO gain-of-function mutations are associated with basal cell carcinoma (PMID: 25085664) and several missense mutations are associated with resistance to Hedgehog pathway inhibitors (PMID: 29175550, PMID: 25306392).
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