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| Gene Symbol | SPI1 | ||||||||||
| Synonyms | AGM10 | OF | PU.1 | SFPI1 | SPI-1 | SPI-A | ||||||||||
| Gene Description | SPI1, Spi-1 proto-oncogene, is a member of the ETS family of transcription factors that functions in regulation of hematopoiesis (PMID: 20520638, PMID: 17374502, PMID: 7819272), and plays a role in tissue fibrosis (PMID: 30700907). SPI1 fusions have been identified in T-cell acute lymphoblastic leukemia (PMID: 34230493, PMID: 28671687), mutations have been observed in Waldenstrom macroglobulinemia and acute myeloid leukemia (PMID: 31018969), and increased expression has been demonstrated in melanoma (PMID: 37539493). | ||||||||||
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