Gene Detail

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Gene Symbol SRC
Synonyms ASV | c-SRC | p60-Src | SRC1 | THC6
Gene Description SRC, SRC proto-oncogene, non-receptor tyrosine kinase, is a member of mutliple signaling pathways, playing a role in a variety of cellular processes including proliferation, differentiation, survival, motility, and angiogenesis (PMID: 19581523). Activation and/or overexpression of SRC has been observed in many cancers (PMID: 24788409), and SRC activating mutations, although rare, have been identified in colon cancer (PMID: 9988270, PMID: 19581523).

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Molecular Profile Protein Effect Treatment Approaches
SRC A91V unknown
SRC act mut gain of function Bosutinib Dasatinib
SRC amp no effect
ROS1 fusion ERBB2 amp NOTCH1 amp SRC amp STK11 amp
SRC C501R unknown
SRC D120N unknown
SRC D351N unknown
SRC D389E unknown
SRC D407H loss of function - predicted
SRC D407N unknown
SRC D521N unknown
SRC D521W unknown
SRC E342K unknown
SRC E527K gain of function Bosutinib Dasatinib
ERBB2 amp SRC E527K
SRC F408A loss of function - predicted
SRC F408G loss of function - predicted
SRC G133C unknown
SRC G347E unknown
SRC I113F unknown
SRC I339W unknown
SRC inact mut loss of function
SRC K155R unknown
SRC K184R unknown
SRC K198R unknown
SRC K298E loss of function - predicted
SRC K298M loss of function
SRC K298R loss of function
SRC K318R gain of function
SRC K319R unknown
SRC K40R unknown
SRC K5R loss of function
SRC K7R loss of function
SRC K9R loss of function
SRC L320I unknown
SRC mutant unknown
SRC over exp no effect
ALK fusion SRC over exp
ERBB2 over exp PIK3CA H1047R SRC over exp
SRC P136S unknown
SRC P171Q unknown
SRC P171R unknown
SRC P307R loss of function - predicted
SRC P428S unknown
SRC P506L unknown
SRC positive unknown
EML4 - ALK SRC pos
ALK rearrange SRC pos
SRC Q256fs loss of function - predicted
SRC Q529H loss of function - predicted
SRC Q531* gain of function Bosutinib Dasatinib
SRC R163W unknown
SRC R220S unknown
SRC R483W unknown
SRC R98W gain of function
SRC S225I unknown
SRC S269L unknown
SRC T183M unknown
SRC T341G loss of function - predicted
SRC T341I gain of function Bosutinib
IDH1 R132C SRC T341I
SRC T341M gain of function Bosutinib Dasatinib
SRC T341R loss of function - predicted
SRC V140M unknown
SRC W121C unknown
SRC W121R gain of function
SRC W263A loss of function - predicted
SRC wild-type no effect
SRC Y419F loss of function
SRC Y530* unknown Bosutinib Dasatinib
SRC Y530F gain of function