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Gene Symbol STAT6
Synonyms D12S1644 | HIES6 | IL-4-STAT | STAT6B | STAT6C
Gene Description STAT6, signal transducer and activator of transcription 6, is a STAT family transcription factor (PMID: 31605750) that mediates IL-4/13 signaling and differentiation of Th2 immune cells (PMID: 24470978). Inhibition of Stat6 phosphorylation may enhance the response to 5-fluorouracil in colon cancer (PMID: 32244885), overexpression has been reported in basal cell carcinoma (PMID: 31323143), and NAB2-STAT6 fusions are recurrent in solitary fibrous tumors (PMID: 23313954, PMID: 23313952).
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