Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||ADAM18 | CD156B | CSVP | NISBD | NISBD1 | TACE|
|Gene Description||ADAM17, ADAM metallopeptidase domain 17, is a member of the disintegrin and metalloprotease domain family, that functions in proteolytic processing of a number of membrane-bound substrates, including TNF-alpha and EGFR ligands, and plays a role in immunity, development, and inflammation (PMID: 31060243, PMID: 30992230). ADAM17 missense mutations have been observed in colon cancer (PMID: 31060243) and altered expression has been reported in lung cancer (PMID: 30833304).|