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Gene Symbol ELOC
Synonyms SIII | TCEB1
Gene Description ELOC, elongin C, is a component of RNA polymerase II elongation factor complex that promotes mRNA elongation (PMID: 7660129), and also a subunit of the VHL tumor suppressor complex that activates HIF1alpha ubiquitination (PMID: 10973499). ELOC mutations have been identified in clear-cell renal cell carcinoma (PMID: 23797736), ELOC amplification and overexpression have been identified in prostate cancer (PMID: 12004003).
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