Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol ELOC
Synonyms SIII | TCEB1
Gene Description ELOC, elongin C, is a component of RNA polymerase II elongation factor complex that promotes mRNA elongation (PMID: 7660129), and also a subunit of the VHL tumor suppressor complex that activates HIF1alpha ubiquitination (PMID: 10973499). ELOC mutations have been identified in clear-cell renal cell carcinoma (PMID: 23797736), ELOC amplification and overexpression have been identified in prostate cancer (PMID: 12004003).


Additional content available in CKB BOOST