Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol TPBG
Synonyms 5T4 | 5T4AG | M6P1 | WAIF1
Gene Description TPBG, trophoblast glycoprotein, is a transmembrane protein involved in inhibition of the Wnt/B-catenin pathway (PMID: 22100263, PMID: 24582434), and has been found to play a role in cytoskeletal organization (PMID: 8895545, PMID: 7593330), cellular motility (PMID: 8895545, PMID: 7593330, PMID: 20376365), angiogenesis (PMID: 31018661), and the epithelial-mesenchymal transition (PMID: 17507657). Overexpression of TPBG has been identified in a variety of solid tumors including malignant pleural mesothelioma (PMID: 22498111), and bladder cancer, breast cancer, cervical cancer, and lung cancer (PMID: 2404511).
Additional content available in CKB BOOST