Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol TRIO
Synonyms ARHGEF23 | MEBAS | MRD44 | MRD63 | tgat
Gene Description TRIO, trio Rho guanosine nucleotide exchange factor, promotes the exchange of GDP for GTP to activate Rho GTPases and plays a role in cellular functions related to growth and migration including cytoskeletal remodeling, neurite outgrowth, and axon guidance (PMID: 11146652, PMID: 11864571, PMID: 10798396, PMID: 8643598). Amplification and overexpression of TRIO has been associated with soft tissue sarcoma (PMID: 16752383) and urinary bladder cancer (PMID: 15215162), a TRIO fusion with TERT has been identified in spindle cell liposarcoma (PMID: 30793229), and TRIO mutations have been identified in gastric cancer and colon cancer (PMID: 28224356).
Additional content available in CKB BOOST