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Gene Symbol TNFRSF4
Synonyms ACT35 | CD134 | IMD16 | OX40 | TXGP1L
Gene Description TNFRSF4 (OX40), tumor necrosis factor receptor superfamily member 4, is expressed on activated T-cells and plays a role in immune co-stimulation through enhanced cell proliferation and survival of T-cells (PMID: 28092803). TNFRSF4 (OX40) antibody based therapies that mimic TNFSF4 (OX40L) may activate T-cells in an antitumor response (PMID: 29574275, PMID: 29529339).
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