Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Synonyms||bA386N14.2 | KABUK2 | UTX|
|Gene Description||KDM6A, lysine demethylase 6A, is a Jumonji domain histone demethylase that targets H3 lysine 27 (H3K27) to regulate gene transcription through chromatin remodeling and plays a role in cell growth and differentiation (PMID: 30753822). Altered expression of Kdm6a has been reported in HNSCC and bladder cancer (PMID: 25275298, PMID: 25225064) and mutations have been observed in acute myeloid leukemia, bladder carcinoma, breast cancer, chronic myeloid leukemia, colorectal adenocarcinoma, endometrial adenocarcinoma, clear cell renal cell carcinoma, and glioblastoma (PMID: 30753822).|