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Gene Symbol EZR
Synonyms CVIL | CVL | HEL-S-105 | VIL2
Gene Description EZR, ezrin, is a member of the ERM family that links the cytoplasm to the actin cytoskeleton (PMID: 24924175) and regulates polarization and migration in leukocytes (PMID: 32098334) and macrophages (PMID: 32064151). EZR plays a role in metastasis in a number of cancer types (PMID: 24924175, PMID: 24421310), although decreased Ezr expression has been associated with decreased survival in clear cell renal carcinoma (PMID: 31648868), and an EZR-ROS1 fusion has been identified in lung cancer (PMID: 25667280, PMID: 22327623).
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