Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol XRCC4
Synonyms SSMED
Gene Description XRCC4, X-ray repair cross complementing 4, is an XRCC gene family member that is involved in DNA non-homologous end joining (PMID: 15279796). XRCC4 variants may confer increased cancer risk in a variety of cancers (PMID: 18991789), including cervical cancer (PMID: 31250713), and Xrcc4 overexpression has been observed in hepatocellular carcinoma (PMID: 29152133).


Additional content available in CKB BOOST