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Gene Symbol TRIM8
Synonyms FSGSNEDS | GERP | RNF27
Gene Description TRIM8, tripartite motif containing 8, encodes an E3 ubiquitin ligase (PMID: 33807506) that interacts with and regulates the activity of Socs1, a suppressor of cytokine signaling, (PMID: 12163497), and plays a role in regulating Tp53 activity (PMID: 22262183, PMID: 28327152), modulation of Stat3 activity via inhibition of Stat3 inhibitor, Pias3 (PMID: 20516148), and in regulating interferon production and TLR3/TLR4 dependent innate immune responses (PMID: 31799391, PMID: 28747347). A fusion with FGFR2 and TRIM8 has been identified in cholangiocarcinoma (PMID: 33218975).
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