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Gene Symbol | ARID1A | ||||||||||
Synonyms | B120 | BAF250 | BAF250a | BM029 | C1orf4 | CSS2 | ELD | hELD | hOSA1 | MRD14 | OSA1 | P270 | SMARCF1 | ||||||||||
Gene Description | ARID1A, AT-rich interaction domain 1A, is a member of the cBaF subunit (PMID: 32303701) of the SWI/SNF chromatin remodeling complex and is involved in cell-cycle activation (PMID: 29136504). ARID1A has been reported to influence PI3K/AKT pathways (PMID: 24618703), and loss of function is commonly found in ovarian clear cell carcinoma (PMID: 32020380, PMID: 32027624), gastric, colorectal (PMID: 28937020), and bladder cancers (PMID: 28583311), while in liver cancer, Arida1a has a context dependent role (PMID: 29136504) and ARID1A promoter hypermethylation has been observed in squamous cell carcinoma (PMID: 32015157). | ||||||||||
|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ARID1A A1434V | unknown | |
ARID1A A1522Pfs*5 | loss of function - predicted | EZH2 inhibitor |
ARID1A A1522T | unknown | |
ARID1A A1559* | loss of function - predicted | EZH2 inhibitor |
ARID1A A1682fs | loss of function - predicted | EZH2 inhibitor |
ARID1A A1757S | unknown | |
ARID1A A1978Sfs*36 | loss of function - predicted | EZH2 inhibitor |
ARID1A A2175fs | unknown | |
ARID1A A2205T | unknown | |
ARID1A A339Gfs*61 | loss of function - predicted | EZH2 inhibitor |
ARID1A A339Lfs*24 | loss of function - predicted | EZH2 inhibitor |
ARID1A A345P | unknown | |
ARID1A A345_A349del | loss of function | EZH2 inhibitor |
ARID1A A35Gfs*76 | loss of function - predicted | EZH2 inhibitor |
ARID1A amp | no effect | |
ARID1A C2163R | unknown | |
ARID1A D1838* | loss of function - predicted | EZH2 inhibitor |
ARID1A D1850fs | loss of function - predicted | EZH2 inhibitor |
ARID1A D1850Gfs*4 | loss of function - predicted | EZH2 inhibitor |
ARID1A D1850Tfs*33 | loss of function - predicted | EZH2 inhibitor |
ARID1A D2086N | unknown | |
ARID1A D2157N | unknown | |
ARID1A D734G | unknown | |
ARID1A dec exp PIK3CA act mut | ||
ARID1A dec exp | no effect | |
ARID1A del | loss of function | EZH2 inhibitor |
ARID1A E1006* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1019Q | unknown | |
ARID1A E1387* | loss of function - predicted | |
ARID1A E1596* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1718* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1733* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1764* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1776* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1777* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1779G | unknown | |
ARID1A E1780* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1799fs | loss of function - predicted | EZH2 inhibitor |
ARID1A E1836* | loss of function - predicted | EZH2 inhibitor |
ARID1A E1964* | loss of function - predicted | EZH2 inhibitor |
ARID1A E2000Q | unknown | |
ARID1A E2047* | unknown | |
ARID1A E2058* | unknown | |
ARID1A E654Gfs*9 | loss of function - predicted | EZH2 inhibitor |
ARID1A E896* | loss of function - predicted | EZH2 inhibitor |
ARID1A E992* | loss of function - predicted | EZH2 inhibitor |
ARID1A F1118fs | loss of function - predicted | EZH2 inhibitor |
ARID1A F1823fs | loss of function - predicted | EZH2 inhibitor |
ARID1A F1859fs | loss of function - predicted | EZH2 inhibitor |
ARID1A F2141Sfs*59 | loss of function - predicted | |
ARID1A F2208fs | unknown | |
ARID1A G108fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G1295fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G1317W | unknown | |
ARID1A G1351fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G1450fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G1711fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G1729D | unknown | |
ARID1A G1847fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G1848fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G1848W | unknown | |
ARID1A G1996D | unknown | |
ARID1A G2087E | loss of function - predicted | |
ARID1A G2087K | unknown | |
ARID1A G2087R | loss of function - predicted | EZH2 inhibitor |
ARID1A G272fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G276* | loss of function - predicted | EZH2 inhibitor |
ARID1A G276Efs*87 | loss of function - predicted | EZH2 inhibitor |
ARID1A G277fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G283fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G284fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G313E | unknown | |
ARID1A G319fs | loss of function - predicted | EZH2 inhibitor |
ARID1A G671Efs*71 | loss of function - predicted | EZH2 inhibitor |
ARID1A G691D | unknown | |
ARID1A G83Wfs*28 | loss of function - predicted | EZH2 inhibitor |
ARID1A G925* | loss of function - predicted | EZH2 inhibitor |
ARID1A H203fs | loss of function - predicted | EZH2 inhibitor |
ARID1A H203Q | unknown | |
ARID1A I1954fs | loss of function - predicted | EZH2 inhibitor |
ARID1A I1954Nfs*9 | loss of function - predicted | |
ARID1A I2127M | unknown | |
ARID1A I2135_L2136del | unknown | |
ARID1A I2185fs | unknown | |
ARID1A I832fs | loss of function - predicted | |
ARID1A I908fs | loss of function - predicted | EZH2 inhibitor |
ARID1A inact mut | loss of function | EZH2 inhibitor |
ARID1A K1071fs | loss of function - predicted | EZH2 inhibitor |
ARID1A K1072Nfs*21 | loss of function - predicted | EZH2 inhibitor |
ARID1A K1603* | loss of function - predicted | EZH2 inhibitor |
ARID1A K1862N | unknown | |
ARID1A K1953Rfs*3 | loss of function - predicted | |
ARID1A K996N | unknown | |
ARID1A L1092* | loss of function - predicted | EZH2 inhibitor |
ARID1A L1713P | unknown | |
ARID1A L1866fs | loss of function - predicted | EZH2 inhibitor |
ARID1A L2009del | loss of function | |
ARID1A L2009_L2017del | loss of function | EZH2 inhibitor |
ARID1A L2117fs | unknown | |
ARID1A L2239P | unknown | |
ARID1A L2279fs | unknown | |
ARID1A L657Pfs*81 | loss of function - predicted | EZH2 inhibitor |
ARID1A L714fs | loss of function - predicted | EZH2 inhibitor |
ARID1A loss | loss of function | EZH2 inhibitor |
ARID1A M1154fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Y788* ARID1A M1154fs | ||
ARID1A M1215fs | loss of function - predicted | EZH2 inhibitor |
ARID1A M1224fs | loss of function - predicted | EZH2 inhibitor |
ARID1A M1224V | unknown | |
ARID1A M1318fs | loss of function - predicted | EZH2 inhibitor |
ARID1A M1532fs | loss of function - predicted | EZH2 inhibitor |
ARID1A M918V | unknown | |
ARID1A M923Hfs*13 | loss of function - predicted | EZH2 inhibitor |
ARID1A mutant | unknown | |
ARID1A mut PIK3CA act mut | ||
ARID1A N1192fs | loss of function - predicted | EZH2 inhibitor |
ARID1A N1270Mfs*19 | loss of function - predicted | |
ARID1A N1705S | unknown | |
ARID1A N1800Y | unknown | |
ARID1A N2109Ffs*37 | unknown | |
ARID1A N472S | unknown | |
ARID1A N917fs | loss of function - predicted | EZH2 inhibitor |
ARID1A N983del | unknown | |
ARID1A negative | loss of function | EZH2 inhibitor |
ARID1A P1048S | unknown | |
ARID1A P1144S | unknown | |
ARID1A P1326Rfs*155 | loss of function - predicted | EZH2 inhibitor |
ARID1A P1326_Q1327del | unknown | |
ARID1A P135Lfs*96 | loss of function - predicted | EZH2 inhibitor |
ARID1A P158S | unknown | |
ARID1A P1619L | unknown | |
ARID1A P1867fs | loss of function - predicted | EZH2 inhibitor |
ARID1A P1898Hfs*25 | loss of function - predicted | EZH2 inhibitor |
ARID1A P20_P21dup | loss of function | EZH2 inhibitor |
ARID1A P2114L | unknown | |
ARID1A P2114Q | unknown | |
ARID1A P224fs | loss of function - predicted | EZH2 inhibitor |
ARID1A P224Rfs*8 | loss of function - predicted | EZH2 inhibitor |
ARID1A P478del | unknown | |
ARID1A P531L | unknown | |
ARID1A P65Rfs*36 | loss of function - predicted | |
ARID1A P725fs | loss of function - predicted | EZH2 inhibitor |
ARID1A P726fs | loss of function - predicted | EZH2 inhibitor |
ARID1A P773S | unknown | |
ARID1A P776L | unknown | |
ARID1A P776R | unknown | |
ARID1A P885L | unknown | |
ARID1A P886Tfs*49 | loss of function - predicted | EZH2 inhibitor |
ARID1A P887S | unknown | |
ARID1A P94Lfs*7 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1095* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1131* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1142* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1148* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1172* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1200* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1212* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1250* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1327Afs*11 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1327fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1334del | unknown | |
ARID1A Q1334_R1335insQ | loss of function | EZH2 inhibitor |
ARID1A Q1342fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1346* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1397fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1401* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1403* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1409* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1454* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1474* | loss of function - predicted | |
ARID1A Q1479* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1493* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1512* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1519* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1519fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1519H | unknown | |
ARID1A Q1519Pfs*13 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1519Rfs*8 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1584* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1631* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1741* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1835* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1835* ARID1A Q2115* | ||
ARID1A Q1856* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q1856H | unknown | |
ARID1A Q1894* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q199* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q199fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q2039fs | unknown | |
ARID1A Q2070* | unknown | |
ARID1A Q2115* | loss of function - predicted | |
ARID1A Q2176fs | unknown | |
ARID1A Q2188* | unknown | |
ARID1A Q2209* | unknown | |
ARID1A Q2209Sfs*22 | unknown | |
ARID1A Q2210* | unknown | |
ARID1A Q268* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q288Pfs*112 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q321Rfs*42 | loss of function - predicted | |
ARID1A Q372* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q372Afs*28 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q372fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q372Sfs*19 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q393* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q393fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q403* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q405* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q449* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q456* | loss of function | EZH2 inhibitor |
ARID1A Q474* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q479* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q480* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q492H | unknown | |
ARID1A Q502* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q507fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q515* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q528* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q528L | unknown | |
ARID1A Q537* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q543* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q546Rfs*73 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q548fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q561H | unknown | |
ARID1A Q566* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q581* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q585* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q586* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q594R | unknown | |
ARID1A Q611* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q611H | unknown | |
ARID1A Q611Rfs*11 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q633* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q670* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q708* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q758Rfs*75 | loss of function - predicted | EZH2 inhibitor |
ARID1A Y551Lfs*72 ARID1A Q758Rfs*75 | ||
ARID1A Q766Pfs*51 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q790* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q802Vfs*32 | loss of function - predicted | EZH2 inhibitor |
ARID1A Q840R | unknown | |
ARID1A Q878* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q920* | loss of function - predicted | EZH2 inhibitor |
ARID1A Q920fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Q944* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1046K | unknown | |
ARID1A R1223C | unknown | |
ARID1A R1223H | unknown | |
ARID1A R1262H | unknown | |
ARID1A R1276* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1335* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1335L | unknown | |
ARID1A R1446* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1461* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1528* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1658Q | unknown | |
ARID1A R1721* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1721fs | loss of function - predicted | EZH2 inhibitor |
ARID1A R1721P | unknown | |
ARID1A R1722* | loss of function - predicted | EZH2 inhibitor |
ARID1A R1906P | unknown | |
ARID1A R1906Q | unknown | |
ARID1A R1989* | loss of function - predicted | EZH2 inhibitor |
ARID1A R2143C | unknown | |
ARID1A R2143H | unknown | |
ARID1A R2158* | loss of function - predicted | |
ARID1A R2158fs | unknown | |
ARID1A R2158Q | unknown | |
ARID1A R2232W | unknown | |
ARID1A R693* | loss of function - predicted | EZH2 inhibitor |
ARID1A R727fs | loss of function - predicted | EZH2 inhibitor |
ARID1A R750* | loss of function - predicted | EZH2 inhibitor |
ARID1A R774Efs*55 | loss of function - predicted | EZH2 inhibitor |
ARID1A S1000F | unknown | |
ARID1A S1000Y | unknown | |
ARID1A S1090I | unknown | |
ARID1A S1149* | loss of function - predicted | EZH2 inhibitor |
ARID1A S1153fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S1184fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S1197C | unknown | |
ARID1A S1197P | unknown | |
ARID1A S11fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S1248* | loss of function - predicted | EZH2 inhibitor |
ARID1A S138* | loss of function - predicted | EZH2 inhibitor |
ARID1A S1623* | loss of function - predicted | EZH2 inhibitor |
ARID1A S1707G | unknown | |
ARID1A S1791* | loss of function - predicted | EZH2 inhibitor |
ARID1A S1868fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S186_G187del | unknown | |
ARID1A S1985P | unknown | |
ARID1A S1992* | unknown | |
ARID1A S1992P | unknown | |
ARID1A S2104F | unknown | |
ARID1A S2104P | unknown | |
ARID1A S2191_G2193del | unknown | |
ARID1A S2269L | unknown | |
ARID1A S258C | unknown | |
ARID1A S261* | loss of function - predicted | EZH2 inhibitor |
ARID1A S264* | loss of function - predicted | EZH2 inhibitor |
ARID1A S366Afs*25 | loss of function - predicted | EZH2 inhibitor |
ARID1A S584fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S617* | loss of function - predicted | EZH2 inhibitor |
ARID1A S621fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S664* | loss of function - predicted | EZH2 inhibitor |
ARID1A S674fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S705fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S711* | loss of function - predicted | EZH2 inhibitor |
ARID1A S735N | unknown | |
ARID1A S769* | loss of function - predicted | EZH2 inhibitor |
ARID1A S825fs | loss of function - predicted | EZH2 inhibitor |
ARID1A S958Lfs*10 | loss of function - predicted | EZH2 inhibitor |
ARID1A T1003fs | loss of function - predicted | EZH2 inhibitor |
ARID1A T1987S | unknown | |
ARID1A T2063Nfs*36 | unknown | |
ARID1A T2138fs | unknown | |
ARID1A T292fs | loss of function - predicted | EZH2 inhibitor |
ARID1A T292Pfs*71 | loss of function - predicted | |
ARID1A T294Pfs*69 | loss of function - predicted | EZH2 inhibitor |
ARID1A T897Lfs*22 | loss of function - predicted | EZH2 inhibitor |
ARID1A T979fs | loss of function - predicted | EZH2 inhibitor |
ARID1A V1561fs | loss of function - predicted | EZH2 inhibitor |
ARID1A V1817I | unknown | |
ARID1A V1982fs | loss of function - predicted | EZH2 inhibitor |
ARID1A W1073* | loss of function - predicted | EZH2 inhibitor |
ARID1A W1545* | loss of function - predicted | EZH2 inhibitor |
ARID1A W1670* | loss of function - predicted | EZH2 inhibitor |
ARID1A W1973* | loss of function - predicted | EZH2 inhibitor |
ARID1A wild-type | no effect | |
ARID1A Y1285fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Y1324fs | loss of function - predicted | EZH2 inhibitor |
ARID1A Y1431* | loss of function - predicted | EZH2 inhibitor |
ARID1A Y2031* | unknown | |
ARID1A Y2076* | unknown | |
ARID1A Y2076fs | unknown | |
ARID1A Y2148* | unknown | |
ARID1A Y2254* | loss of function - predicted | EZH2 inhibitor |
ARID1A Y2254fs | unknown | |
ARID1A Y395* | loss of function - predicted | EZH2 inhibitor |
ARID1A Y518* | loss of function - predicted | EZH2 inhibitor |
ARID1A Y551Lfs*72 | loss of function - predicted | EZH2 inhibitor |
ARID1A Y551Tfs*68 | loss of function - predicted | EZH2 inhibitor |
ARID1A Y592* | loss of function - predicted | EZH2 inhibitor |
ARID1A Y788* | loss of function - predicted | EZH2 inhibitor |
ARID1A Y823fs | loss of function - predicted | EZH2 inhibitor |