Gene Detail

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Gene Symbol ARID1A
Synonyms B120 | BAF250 | BAF250a | BM029 | C1orf4 | CSS2 | ELD | hELD | hOSA1 | MRD14 | OSA1 | P270 | SMARCF1
Gene Description ARID1A, AT-rich interaction domain 1A, is a member of the cBaF subunit (PMID: 32303701) of the SWI/SNF chromatin remodeling complex and is involved in cell-cycle activation (PMID: 29136504). ARID1A has been reported to influence PI3K/AKT pathways (PMID: 24618703), and loss of function is commonly found in ovarian clear cell carcinoma (PMID: 32020380, PMID: 32027624), gastric, colorectal (PMID: 28937020), and bladder cancers (PMID: 28583311), while in liver cancer, Arida1a has a context dependent role (PMID: 29136504) and ARID1A promoter hypermethylation has been observed in squamous cell carcinoma (PMID: 32015157).

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Molecular Profile Protein Effect Treatment Approaches
ARID1A A1434V unknown
ARID1A A1522Pfs*5 loss of function - predicted
ARID1A A1522T unknown
ARID1A A1559* loss of function - predicted EZH2 inhibitor
ARID1A A1757S unknown
ARID1A A1978Sfs*36 loss of function - predicted EZH2 inhibitor
ARID1A A2175fs unknown
ARID1A A2205T unknown
ARID1A A339Gfs*61 loss of function - predicted
ARID1A A339Lfs*24 loss of function - predicted
ARID1A A344_A348del loss of function EZH2 inhibitor
ARID1A A345P unknown
ARID1A amp no effect
ARID1A - MAST2 gain of function - predicted EZH2 inhibitor
ARID1A C2163R unknown
ARID1A D1838* loss of function - predicted EZH2 inhibitor
ARID1A D1850fs loss of function - predicted
ARID1A D1850Gfs*4 loss of function - predicted
ARID1A D2086N unknown
ARID1A D2157N unknown
ARID1A D734G unknown
ARID1A dec exp PIK3CA act mut
ARID1A dec exp no effect
AKT1 pos ARID1A dec exp
ARID1A del loss of function
ARID1A E1596* loss of function - predicted EZH2 inhibitor
ARID1A E1718* loss of function - predicted
ARID1A E1733* loss of function - predicted EZH2 inhibitor
ARID1A E1764* loss of function - predicted EZH2 inhibitor
ARID1A E1776* loss of function - predicted EZH2 inhibitor
ARID1A E1779G unknown
ARID1A E1780* loss of function - predicted EZH2 inhibitor
ARID1A E1836* loss of function - predicted
ARID1A E2000Q unknown
ARID1A E2047* unknown
ARID1A E2058* unknown
ARID1A E654Gfs*9 loss of function - predicted EZH2 inhibitor
ARID1A E992* loss of function - predicted EZH2 inhibitor
ARID1A F1859fs loss of function - predicted EZH2 inhibitor
ARID1A F2208fs unknown
ARID1A G108fs loss of function - predicted EZH2 inhibitor
ARID1A G1317W unknown
ARID1A G1351fs loss of function - predicted
ARID1A G1450fs loss of function - predicted EZH2 inhibitor
ARID1A G1711fs loss of function - predicted EZH2 inhibitor
ARID1A G1729D unknown
ARID1A G1847fs loss of function - predicted EZH2 inhibitor
ARID1A G1848fs loss of function - predicted EZH2 inhibitor
ARID1A G1848W unknown
ARID1A G1996D unknown
ARID1A G2087E unknown
ARID1A G2087K unknown
ARID1A G2087R loss of function - predicted
ARID1A G272fs loss of function - predicted
ARID1A G276* loss of function - predicted EZH2 inhibitor
ARID1A G276Efs*87 loss of function - predicted EZH2 inhibitor
ARID1A G283fs loss of function - predicted
ARID1A G313E unknown
ARID1A G319fs loss of function - predicted EZH2 inhibitor
ARID1A G671Efs*71 loss of function - predicted EZH2 inhibitor
ARID1A G691D unknown
ARID1A G925* loss of function - predicted EZH2 inhibitor
ARID1A H203fs loss of function - predicted EZH2 inhibitor
ARID1A H203Q unknown
ARID1A I1954fs loss of function - predicted EZH2 inhibitor
ARID1A I2127M unknown
ARID1A I2135_L2136del unknown
ARID1A I2185fs unknown
ARID1A I908fs loss of function - predicted EZH2 inhibitor
ARID1A inact mut loss of function EZH2 inhibitor
ARID1A K1071fs loss of function - predicted EZH2 inhibitor
ARID1A K1603* loss of function - predicted
ARID1A K1862N unknown
ARID1A K996N unknown
ARID1A L1092* loss of function - predicted EZH2 inhibitor
ARID1A L1713P unknown
ARID1A L2007del loss of function EZH2 inhibitor
ARID1A L2009_L2017del loss of function EZH2 inhibitor
ARID1A L2239P unknown
ARID1A L2279fs unknown
ARID1A L657Pfs*81 loss of function - predicted EZH2 inhibitor
ARID1A L714fs loss of function - predicted EZH2 inhibitor
ARID1A loss loss of function EZH2 inhibitor
ARID1A loss ERBB2 amp
ARID1A M1215fs loss of function - predicted EZH2 inhibitor
ARID1A M1224fs loss of function - predicted EZH2 inhibitor
ARID1A M1224V unknown
ARID1A M1318fs loss of function - predicted EZH2 inhibitor
ARID1A M918V unknown
ARID1A M923Hfs*13 loss of function - predicted
ARID1A mutant unknown
ARID1A mut PIK3CA act mut
ARID1A N1705S unknown
ARID1A N1800Y unknown
ARID1A N2109Ffs*37 unknown EZH2 inhibitor
ARID1A N917fs loss of function - predicted EZH2 inhibitor
ARID1A N982del unknown
ARID1A negative loss of function EZH2 inhibitor
ARID1A P1048S unknown
ARID1A P1144S unknown
ARID1A P1326Rfs*155 loss of function - predicted
ARID1A P1326_Q1327del unknown
ARID1A P135Lfs*96 loss of function - predicted
ARID1A P1619L unknown
ARID1A P1898Hfs*25 loss of function - predicted
ARID1A P20_P21dup loss of function EZH2 inhibitor
ARID1A P2114L unknown
ARID1A P2114Q unknown
ARID1A P224fs loss of function - predicted EZH2 inhibitor
ARID1A P224Rfs*8 loss of function - predicted
ARID1A P478del unknown
ARID1A P531L unknown
ARID1A P725fs loss of function - predicted EZH2 inhibitor
ARID1A P773S unknown
ARID1A P776L unknown
ARID1A P776R unknown
ARID1A P885L unknown
ARID1A P886Tfs*49 loss of function - predicted
ARID1A P887S unknown
ARID1A P94Lfs*7 loss of function - predicted
ARID1A Q1095* loss of function - predicted EZH2 inhibitor
ARID1A Q1131* loss of function - predicted EZH2 inhibitor
ARID1A Q1142* loss of function - predicted
ARID1A Q1148* loss of function - predicted EZH2 inhibitor
ARID1A Q1172* loss of function - predicted EZH2 inhibitor
ARID1A Q1212* loss of function - predicted EZH2 inhibitor
ARID1A Q1250* loss of function - predicted
ARID1A Q1327del unknown
ARID1A Q1327fs loss of function - predicted
ARID1A Q1334del unknown
ARID1A Q1334_R1335insQ loss of function EZH2 inhibitor
ARID1A Q1342fs loss of function - predicted EZH2 inhibitor
ARID1A Q1346* loss of function - predicted
ARID1A Q1401* loss of function - predicted EZH2 inhibitor
ARID1A Q1409* loss of function - predicted EZH2 inhibitor
ARID1A Q1479* loss of function - predicted EZH2 inhibitor
ARID1A Q1493* loss of function - predicted EZH2 inhibitor
ARID1A Q1512* loss of function - predicted
ARID1A Q1519* loss of function - predicted
ARID1A Q1519fs loss of function - predicted EZH2 inhibitor
ARID1A Q1519H unknown
ARID1A Q1519Pfs*13 loss of function - predicted EZH2 inhibitor
ARID1A Q1519Rfs*8 loss of function - predicted
ARID1A Q1584* loss of function - predicted EZH2 inhibitor
ARID1A Q1631* loss of function - predicted EZH2 inhibitor
ARID1A Q1741* loss of function - predicted EZH2 inhibitor
ARID1A Q1856* loss of function - predicted EZH2 inhibitor
ARID1A Q1856H unknown
ARID1A Q1894* loss of function - predicted EZH2 inhibitor
ARID1A Q199fs loss of function - predicted EZH2 inhibitor
ARID1A Q2039fs unknown
ARID1A Q2070* unknown
ARID1A Q2209* unknown
ARID1A Q288Pfs*112 loss of function - predicted
ARID1A Q372Afs*28 loss of function - predicted EZH2 inhibitor
ARID1A Q372Sfs*19 loss of function - predicted
ARID1A Q393* loss of function - predicted EZH2 inhibitor
ARID1A Q393fs loss of function - predicted EZH2 inhibitor
ARID1A Q403* loss of function - predicted EZH2 inhibitor
ARID1A Q449* loss of function - predicted EZH2 inhibitor
ARID1A Q456* loss of function EZH2 inhibitor
ARID1A Q474* loss of function - predicted
ARID1A Q479* loss of function - predicted EZH2 inhibitor
ARID1A Q480* loss of function - predicted EZH2 inhibitor
ARID1A Q492H unknown
ARID1A Q502* loss of function - predicted EZH2 inhibitor
ARID1A Q507fs loss of function - predicted EZH2 inhibitor
ARID1A Q515* loss of function - predicted EZH2 inhibitor
ARID1A Q528* loss of function - predicted EZH2 inhibitor
ARID1A Q528L unknown
ARID1A Q537* loss of function - predicted EZH2 inhibitor
ARID1A Q543* loss of function - predicted EZH2 inhibitor
ARID1A Q546Rfs*73 loss of function - predicted EZH2 inhibitor
ARID1A Q548fs loss of function - predicted EZH2 inhibitor
ARID1A Q561H unknown
ARID1A Q566* loss of function - predicted EZH2 inhibitor
ARID1A Q581* loss of function - predicted EZH2 inhibitor
ARID1A Q585* loss of function - predicted EZH2 inhibitor
ARID1A Q594R unknown
ARID1A Q611H unknown
ARID1A Q611Rfs*11 loss of function - predicted EZH2 inhibitor
ARID1A Q633* loss of function - predicted EZH2 inhibitor
ARID1A Q670* loss of function - predicted EZH2 inhibitor
ARID1A Q708* loss of function - predicted EZH2 inhibitor
ARID1A Q790* loss of function - predicted EZH2 inhibitor
ARID1A Q840R unknown
ARID1A Q878* loss of function - predicted EZH2 inhibitor
ARID1A Q920* loss of function - predicted EZH2 inhibitor
ARID1A Q944* loss of function - predicted EZH2 inhibitor
ARID1A R1046K unknown
ARID1A R1223C unknown
ARID1A R1223H unknown
ARID1A R1262H unknown
ARID1A R1276* loss of function - predicted EZH2 inhibitor
ARID1A R1335* loss of function - predicted EZH2 inhibitor
ARID1A R1446* loss of function - predicted EZH2 inhibitor
ARID1A R1461* loss of function - predicted EZH2 inhibitor
ARID1A R1528* loss of function - predicted EZH2 inhibitor
ARID1A R1658Q unknown
ARID1A R1721* loss of function - predicted EZH2 inhibitor
ARID1A R1721fs loss of function - predicted EZH2 inhibitor
ARID1A R1722* loss of function - predicted EZH2 inhibitor
ARID1A R1906P unknown
ARID1A R1906Q unknown
ARID1A R1989* loss of function - predicted EZH2 inhibitor
ARID1A R2143C unknown
ARID1A R2143H unknown
ARID1A R2158* unknown
ARID1A R2158fs unknown
ARID1A R2158Q unknown
ARID1A R2232W unknown
ARID1A R693* loss of function - predicted EZH2 inhibitor
ARID1A R727fs loss of function - predicted EZH2 inhibitor
ARID1A R750* loss of function - predicted EZH2 inhibitor
ARID1A R774Efs*55 loss of function - predicted EZH2 inhibitor
ARID1A S1000F unknown
ARID1A S1000Y unknown
ARID1A S1090I unknown
ARID1A S1153fs loss of function - predicted EZH2 inhibitor
ARID1A S1197C unknown
ARID1A S1197P unknown
ARID1A S11fs loss of function - predicted EZH2 inhibitor
ARID1A S1248* loss of function - predicted EZH2 inhibitor
ARID1A S1623* loss of function - predicted
ARID1A S1707G unknown
ARID1A S1791* loss of function - predicted
ARID1A S186_G187del unknown
ARID1A S1992* unknown
ARID1A S1992P unknown
ARID1A S2104F unknown
ARID1A S2104P unknown
ARID1A S2191_G2193del unknown
ARID1A S2269L unknown
ARID1A S261* loss of function - predicted
ARID1A S264* loss of function - predicted
ARID1A S584fs loss of function - predicted
ARID1A S617* loss of function - predicted EZH2 inhibitor
ARID1A S664* loss of function - predicted EZH2 inhibitor
ARID1A S674fs loss of function - predicted EZH2 inhibitor
ARID1A S705fs loss of function - predicted EZH2 inhibitor
ARID1A S735N unknown
ARID1A S769* loss of function - predicted EZH2 inhibitor
ARID1A S825fs loss of function - predicted EZH2 inhibitor
ARID1A S958Lfs*10 loss of function - predicted EZH2 inhibitor
ARID1A T1003fs loss of function - predicted EZH2 inhibitor
ARID1A T1987S unknown
ARID1A T2063Nfs*36 unknown
ARID1A T2138fs unknown
ARID1A T292fs loss of function - predicted EZH2 inhibitor
ARID1A T294Pfs*69 loss of function - predicted EZH2 inhibitor
ARID1A T897Lfs*22 loss of function - predicted
ARID1A V1561fs loss of function - predicted EZH2 inhibitor
ARID1A W1073* loss of function - predicted
ARID1A W1545* loss of function - predicted EZH2 inhibitor
ARID1A W1670* loss of function - predicted EZH2 inhibitor
ARID1A W1973* loss of function - predicted
ARID1A wild-type no effect
ARID1A Y1285fs loss of function - predicted EZH2 inhibitor
ARID1A Y1324fs loss of function - predicted EZH2 inhibitor
ARID1A Y1431* loss of function - predicted
ARID1A Y2031* unknown
ARID1A Y2076* unknown
ARID1A Y2076fs unknown
ARID1A Y2148* unknown
ARID1A Y2254* loss of function - predicted
ARID1A Y2254fs unknown
ARID1A Y395* loss of function - predicted EZH2 inhibitor
ARID1A Y551Tfs*68 loss of function - predicted EZH2 inhibitor
ARID1A Y592* loss of function - predicted EZH2 inhibitor
ARID1A Y823fs loss of function - predicted EZH2 inhibitor