Gene Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene Symbol CASP6
Synonyms MCH2
Gene Description CASP6, caspase 6, is a cysteine-aspartic acid protease that plays a key role in the process of programmed cell death (PMID: 28726391) and axon degeneration (PMID: 30940883). Overexpression and decreased Casp6 expression have been observed in a variety of tumor types (PMID: 28726391), including gastric cancer (PMID: 31611962), and CASP6 somatic mutations have been identified in gastric and colorectal cancer (PMID: 16948818).


Additional content available in CKB BOOST