Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : email@example.com
|Synonyms||BTBD32 | TEF2|
|Gene Description||SPOP, speckle type BTB/POZ protein, is a substrate recognition subunit of the cullin-RING E3 ligase complex and regulates degradation of proteins involved in hormone signaling, epigenetic regulation, gene transcription, cell cycle, and metastasis, thus plays dual roles in carcinogenesis (PMID: 31495053, PMID: 31901237). SPOP mutations are frequently identified in prostate (PMID: 20668451) and endometrial cancer (PMID: 23104009), overexpression of SPOP has been identified in renal cell carcinoma (PMID: 29801752).|