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Gene Symbol HVCN1
Synonyms HV1 | VSOP
Gene Description HVCN1, hydrogen voltage gated channel 1, encodes a voltage-gated proton channel protein involved in regulating B-cell receptor signaling, production of reactive oxygen species, and immune cell proliferation, activation, and migration (PMID: 20139987, PMID: 20346427, PMID: 20961760). HVCN1 mutations have been observed in follicular lymphoma (PMID: 28064239, PMID: 30126979), overexpression of Hvcn1 has been identified in breast cancer (PMID: 22367212), colorectal cancer (PMID: 23940591), chronic lymphocytic leukemia (PMID: 20139987), and alternative expression of a short Hvcn1 isoform may contribute to progression of B-cell malignancies (PMID: 25425665).
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