Gene Detail

Gene Symbol DOT1L
Synonyms DOT1 | KMT4
Gene Description DOT1L, DOT1-like histone H3K79 methyltransferase, mediates histone H3 methylation at lysine 79, a methylation state associated with active gene transcription, and is associated with pathogenesis of mixed lineage leukemia (MLL)-rearranged leukemia (PMID: 24854991). DOT1L amplification and increased protein expression has been reported in pancreatic adenocarcinoma (PMID: 28529740).
Entrez Id 84444
Chromosome 19
Map Location 19p13.3
Canonical Transcript NM_032482

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