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Gene Symbol DOT1L
Synonyms DOT1 | KMT4
Gene Description DOT1L, DOT1 like histone lysine methyltransferase, mediates histone H3 methylation at lysine 79 and is associated with active gene transcription, DNA damage response, and DNA repair (PMID: 30616689). DOT1L is associated with pathogenesis of mixed lineage leukemia (MLL)-rearranged leukemia (PMID: 24854991) and DOT1L amplification and/or overexpression has been reported in pancreatic adenocarcinoma (PMID: 28529740), gastric cancer (PMID: 31939604), and triple negative breast cancer (PMID: 31720371).
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