Gene Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at :

Gene Symbol IRS4
Synonyms CHNG9 | IRS-4 | PY160
Gene Description IRS4, insulin receptor substrate 4, encodes a member of the IRS family of adapter proteins that mediates the activation of diverse signaling pathways (PMID: 19534786) including protein kinase B and Akt (PMID: 10594015), and plays a role in metabolism (PMID: 10077007), differentiation (PMID: 28821740), and transformation (PMID: 19029952). IRS4 mutations have been identified in acute lymphoblastic leukemia (PMID: 21517825), and increased Irs4 expression has been observed in colorectal cancer (PMID: 30410539), hepatocellular carcinoma (PMID: 16871543), and T-cell acute lymphoblastic leukemia (PMID: 19055661).
Additional content available in CKB BOOST