Gene Detail

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Gene Symbol OGT
Synonyms HINCUT-1 | HRNT1 | MRX106 | O-GLCNAC | OGT1
Gene Description OGT, O-linked N-acetylglucosamine (GlcNAc) transferase, catalyzes the addition of an O-GlcNac to serine or threonine residue of the target protein (PMID: 25825515), therefore is involved in diverse cellular processes including metabolism, immune response, neuromuscular functions, epigenetic regulation, and tumorigenesis (PMID: 28488703). OGT fusions have been identified in high-grade serous ovarian carcinoma (PMID: 31745703) and myoepithelioma-like hyalinizing epithelioid tumors (PMID: 31567281), and Ogt overexpression has been identified in esophageal squamous cell carcinoma (PMID: 23554759), lung cancer, and colon cancer (PMID: 21255644).


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