Gene Detail

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Gene Symbol RSPO3
Synonyms CRISTIN1 | PWTSR | THSD2
Gene Description RSPO3, R-spondin 3, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling due to its furin repeat domains (PMID: 24980904). RSPO3 fusions with PTPRK (PTPRK-RPSO3) have been frequently identified in colorectal cancer (PMID: 26924569) and decreased RSPO3 expression has been observed with prostate cancer invasiveness (PMID: 30987640), whereas overexpression of RSPO3 has been observed in bladder cancer (PMID: 30329043).

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
fusion fusion unknown RSPO3 fusion indicates a fusion of the RSPO3 gene, but the fusion partner is unknown.
inact mut unknown loss of function RSPO3 inact mut indicates that this variant results in a loss of function of the Rspo3 protein. However, the specific amino acid change has not been identified.
mutant unknown unknown RSPO3 mutant indicates an unspecified mutation in the RSPO3 gene.