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|Synonyms||CRISTIN1 | PWTSR | THSD2|
|Gene Description||RSPO3, R-spondin 3, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling due to its furin repeat domains (PMID: 24980904). RSPO3 fusions with PTPRK (PTPRK-RPSO3) have been frequently identified in colorectal cancer (PMID: 26924569) and decreased RSPO3 expression has been observed with prostate cancer invasiveness (PMID: 30987640), whereas overexpression of RSPO3 has been observed in bladder cancer (PMID: 30329043).|
|Variant||Impact||Protein Effect||Variant Description||Associated with drug Resistance|
|fusion||fusion||unknown||RSPO3 fusion indicates a fusion of the RSPO3 gene, but the fusion partner is unknown.|
|inact mut||unknown||loss of function||RSPO3 inact mut indicates that this variant results in a loss of function of the Rspo3 protein. However, the specific amino acid change has not been identified.|
|mutant||unknown||unknown||RSPO3 mutant indicates an unspecified mutation in the RSPO3 gene.|