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|Synonyms||CRISTIN1 | PWTSR | THSD2|
|Gene Description||RSPO3, R-spondin 3, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling due to its furin repeat domains (PMID: 24980904). RSPO3 fusions with PTPRK (PTPRK-RPSO3) have been frequently identified in colorectal cancer (PMID: 26924569) and decreased RSPO3 expression has been observed with prostate cancer invasiveness (PMID: 30987640), whereas overexpression of RSPO3 has been observed in bladder cancer (PMID: 30329043).|
|Molecular Profile||Protein Effect||Treatment Approaches|
|RSPO3 dec exp||no effect|
|RSPO3 E66*||loss of function - predicted|
|RSPO3 inact mut||loss of function|
|RSPO3 over exp||no effect|
|RSPO3 R4*||loss of function - predicted|