Gene Detail

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Gene Symbol RSPO3
Synonyms CRISTIN1 | PWTSR | THSD2
Gene Description RSPO3, R-spondin 3, encodes for one of the secreted proteins in the TSR1-containing protein family, which plays a role in canonical Wnt signaling due to its furin repeat domains (PMID: 24980904). RSPO3 fusions with PTPRK (PTPRK-RPSO3) have been frequently identified in colorectal cancer (PMID: 26924569) and decreased RSPO3 expression has been observed with prostate cancer invasiveness (PMID: 30987640), whereas overexpression of RSPO3 has been observed in bladder cancer (PMID: 30329043).

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Molecular Profile Protein Effect Treatment Approaches
RSPO3 A185T unknown
RSPO3 A231V unknown
RSPO3 C105S unknown
RSPO3 C129* unknown
RSPO3 D50H unknown
RSPO3 dec exp no effect
RSPO3 E149K unknown
RSPO3 E178* unknown
RSPO3 E178K unknown
RSPO3 E239D unknown
RSPO3 E239K unknown
RSPO3 E66* loss of function - predicted
RSPO3 E66K unknown
RSPO3 fusion unknown
RSPO3 G123E unknown
RSPO3 G163E unknown
RSPO3 G171E unknown
RSPO3 G212R unknown
RSPO3 G215Efs*69 unknown
RSPO3 H138N unknown
RSPO3 inact mut loss of function
RSPO3 K115Q unknown
RSPO3 K161E unknown
RSPO3 K169N unknown
RSPO3 K58N unknown
RSPO3 L122H unknown
RSPO3 L126F unknown
RSPO3 L55V unknown
RSPO3 mutant unknown
RSPO3 N23K unknown
RSPO3 over exp no effect
RSPO3 P183H unknown
RSPO3 P35L unknown
RSPO3 P35S unknown
RSPO3 Q181H unknown
RSPO3 Q260* unknown
RSPO3 R177* unknown
RSPO3 R257Q unknown
RSPO3 R4* loss of function - predicted
RSPO3 R67T unknown
RSPO3 R88* unknown
RSPO3 R88Q unknown
RSPO3 S265L unknown
RSPO3 T139A unknown
RSPO3 T160K unknown
RSPO3 T193A unknown