Gene Detail

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Gene Symbol PPM1D
Synonyms IDDGIP | JDVS | PP2C-DELTA | WIP1
Gene Description PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D, also known as wild-type p53-induced phosphatase 1 (Wip1), is a nuclear serine/threonine phosphatase that inhibits ATM, CHK2, p38MAPK and TP53 signaling (PMID: 32006900). PPM1D is often amplified in human cancers (PMID: 19879149), including breast cancer (PMID: 32006900), and overexpression is associated with poor prognosis in esophageal (PMID: 30374621) and gastric cancers (PMID: 32006900).


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